At the International Rectal Cancer Meeting 2026 in Lisbon, celebrating 50 years of Total Mesorectal Excision (TME) and the legacy of Professor Bill Heald, leading international experts will gather to discuss the innovations shaping the future of rectal cancer management. Professor Quentin Denost will participate in the session “Rectal Cancer – Recent Innovations” with a lecture entitled “Upcoming Practice-Changing Trials”, focusing on emerging clinical trials that have the potential to redefine treatment standards in the years ahead. This presentation will highlight the most promising advances in organ preservation, treatment personalization, and the optimization of multimodal strategies for rectal cancer care